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There are several matches for 'site-2 protease'.
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1372 matches
showing page 1 of 69
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organism
protein
1)
Homo sapiens
MBTPS2 - Membrane-bound transcription factor
site
-2
protease
; Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by
proteases
within the plane of the membrane. It cleaves sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene transcription. Involved in RIP-mediated regulation of bone formation.
[a.k.a. NM_015884, UPI000021249B, AAD08632.1,
site-2 protease
]
2)
Drosophila melanogaster
S2P - Metalloendopeptidase activity. It is involved in the biological process described with: positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; sterol regulatory element binding protein cleavage; membrane protein intracellular domain proteolysis; positive regulation of DNA-binding transcription factor activity.
[a.k.a. FBgn0033656, S2P-PA, AY071529,
Site-2 protease
]
3)
Homo sapiens
MBTPS1 - Membrane-bound transcription factor
site
-1
protease
; Serine
protease
that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP
-2
), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysos [...]
[a.k.a. URS0000D6EC63, Q24JQ2, CCDS10941.1]
4)
Mus musculus
Mbtps2 - Membrane-bound transcription factor
site
-2
protease
; Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by
proteases
within the plane of the membrane. It cleaves sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene transcription. Involved in RIP-mediated regulation of bone formation; Belongs to the peptidase M50A family.
[a.k.a. Yy2, R-MMU-381119, R-MMU-381033]
5)
Mus musculus
Mbtps1 - Membrane-bound transcription factor
site
-1
protease
; Serine
protease
that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP
-2
), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysos [...]
[a.k.a. Q9WTZ2, NP_062683.3, R-MMU-381119]
6)
Escherichia coli K12
rseA - Anti-sigma factor; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (
site
-1
protease
, S1P, DegS), then within the membrane itself (
site
-2
protease
, S2P, RseP), while cytoplasmic
proteases
finish degrading [...]
[a.k.a. b2572, AAC75625.1, mclA]
7)
Escherichia coli K12
rseP - Inner membrane zinc RIP metalloprotease; A
site
-2
regulated intramembrane
protease
(S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA, residue 'Val-148' of RseA may be required for this. This provides the cell with sigma-E (RpoE) activity through the proteolysis of RseA. Can also cleave sequences in transmembrane regions of other proteins (such as LacY) as well as liberated signal peptides of beta-lactamas [...]
[a.k.a. b0176, AAC73287.1, 3ID1]
8)
Acidovorax citrulli
Aave_1830 -
Site
-2
protease
; TIGRFAM: putative membrane-associated zinc metalloprotease; PFAM: peptidase M50; KEGG: pol:Bpro_2688 peptidase M50, putative membrane-associated zinc metallopeptidase; Metallo peptidase; MEROPS family M50B.
[a.k.a. ABM32414.1, EC 3.4.24.-, ABM32414,
Site-2 protease
,
site-2 protease
, ...]
9)
Acidovorax sp. JS42
Ajs_2578 -
Site
-2
protease
; TIGRFAM: putative membrane-associated zinc metalloprotease; PFAM: peptidase M50; KEGG: pol:Bpro_2688 peptidase M50, putative membrane-associated zinc metallopeptidase; Metallo peptidase; MEROPS family M50B.
[a.k.a. ABM42736.1, A1W911, ajs:Ajs_2578,
Site-2 protease
,
site-2 protease
, ...]
10)
Alkalilimnicola ehrlichii
Mlg_1856 -
Site
-2
protease
; TIGRFAM: putative membrane-associated zinc metalloprotease; PFAM: PDZ/DHR/GLGF domain protein; peptidase M50; KEGG: noc:Noc_0815 peptidase M50, putative membrane-associated zinc metallopeptidase; Metallo peptidase; MEROPS family M50B.
[a.k.a. ABI57200.1, EC 3.4.24.-,
Site-2 protease
,
site-2 protease
]
11)
Alteromonas sp. ALT199
EXF47897.1 -
Site
-2
protease
; IMG reference gene:2526020577; PFAM: Peptidase family M50; PDZ domain; PDZ domain (Also known as DHR or GLGF); TIGRFAM: RIP metalloprotease RseP.
[a.k.a. H978DRAFT_0371, WP_025254296.1, A0A010PCJ6_9ALTE,
Site-2 protease
,
site-2 protease
, ...]
12)
Bacteroides helcogenes
ADV45145.1 -
Site
-2
protease
; COGs: COG0750 membrane-associated Zn-dependent
protease
1; InterPro IPR008915; KEGG: bfs:BF3491 putative
protease
; PFAM: peptidase M50; SPTR: Putative uncharacterized protein; PFAM: Peptidase family M50; TIGRFAM: RIP metalloprotease RseP.
[a.k.a. Bache_3221, EC 3.4.24.-, ADV45145,
Site-2 protease
,
site-2 protease
, ...]
13)
Bacteroides uniformis
rseP -
Site
-2
protease
.
[a.k.a. ERS852554_02061, CUP86921.1, Bun01g_37050,
Site-2 protease
,
site-2 protease
, ...]
14)
Bartonella apis
AQT44706.1 -
Site
-2
protease
; IMG identifier: 2650557046; IMG locus_tag: Ga0104991_11997.
[a.k.a. BBC0244_009950, A0A1U9MH99, AQT44706,
Site-2 protease
,
site-2 protease
, ...]
15)
Belliella baltica
AFL86237.1 -
Site
-2
protease
; PFAM: Peptidase family M50; PDZ domain (Also known as DHR or GLGF); TIGRFAM: RIP metalloprotease RseP.
[a.k.a. Belba_3754, AFL86237, EC 3.4.24.-,
Site-2 protease
,
site-2 protease
, ...]
16)
Bernardetia litoralis
AFM03764.1 -
Site
-2
protease
; PFAM: Peptidase family M50; TIGRFAM: RIP metalloprotease RseP.
[a.k.a. Fleli_1332, EC 3.4.24.-,
Site-2 protease
,
site-2 protease
]
17)
Calditerrivibrio nitroreducens
ADR19892.1 -
Site
-2
protease
; COGs: COG0750 membrane-associated Zn-dependent
protease
1; InterPro IPR004387: IPR001478: IPR008915; KEGG: ddf:DEFDS_0124 membrane-associated zinc metalloprotease; PFAM: peptidase M50; PDZ/DHR/GLGF domain protein; SMART: PDZ/DHR/GLGF domain protein; SPTR: Membrane-associated zinc metalloprotease; TIGRFAM: membrane-associated zinc metalloprotease; PFAM: Peptidase family M50; PDZ domain (Also known as DHR or GLGF); TIGRFAM: RIP metalloprotease RseP.
[a.k.a. Calni_1998, E4THF7, EC 3.4.24.-,
Site-2 protease
,
site-2 protease
, ...]
18)
Desulfitobacterium dehalogenans
AFM01393.1 -
Site
-2
protease
; PFAM: Peptidase family M50; PDZ domain (Also known as DHR or GLGF); TIGRFAM: RIP metalloprotease RseP.
[a.k.a. Desde_3101, WP_014794873.1, I4ABQ8_DESDJ,
Site-2 protease
,
site-2 protease
, ...]
19)
Desulfitobacterium dichloroeliminans
AGA70005.1 -
Site
-2
protease
; PFAM: Peptidase family M50; PDZ domain (Also known as DHR or GLGF).
[a.k.a. Desdi_2589, ddl:Desdi_2589, NC_019903.1,
Site-2 protease
,
site-2 protease
, ...]
20)
Desulfobulbus propionicus
ADW16997.1 -
Site
-2
protease
; COGs: COG0750 membrane-associated Zn-dependent
protease
1; InterPro IPR008915: IPR001478: IPR004387; KEGG: dak:DaAHT2_0974 membrane-associated zinc metalloprotease; PFAM: peptidase M50; PDZ/DHR/GLGF domain protein; SMART: PDZ/DHR/GLGF domain protein; SPTR: Membrane-associated zinc metalloprotease; TIGRFAM: membrane-associated zinc metalloprotease; PFAM: Peptidase family M50; PDZ domain (Also known as DHR or GLGF); TIGRFAM: RIP metalloprotease RseP.
[a.k.a. Despr_0823, EC 3.4.24.-, dpr:Despr_0823,
Site-2 protease
,
site-2 protease
, ...]
1372 matches
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